Fig. 2: Substrate scope of enantioselective four-component reactions of alcohol, diazoester, indole and aldehyde derivatives. | Nature Communications

Fig. 2: Substrate scope of enantioselective four-component reactions of alcohol, diazoester, indole and aldehyde derivatives.

From: An enantioselective four-component reaction via assembling two reaction intermediates

Fig. 2

Standard conditions: 1/2/3/4/5a/[Pd]/6a = 0.6/0.3/0.2/0.6/0.1/0.01/0.02 mmol. 2, 3 in 4.0 mL dry DCE was added into a solution of 1, 4, 5a (50 mol%), [Pd] (5 mol%), 6a (10 mol%), and 4 Å MS (50 mg) in 4.0 mL dry DCE via a syringe pump for 60 min, and the resulting mixture was stirred for another 12 h at −20 °C.

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