Fig. 3: Substrate scope of enantioselective four-component reactions of alcohol, diazoester, enamine and aldehyde derivatives.
From: An enantioselective four-component reaction via assembling two reaction intermediates
Standard condition: 1/2/3/4/5b/[PdCl(allyl)]2/6b = 0.18/0.18/0.18/0.15/0.075/0.0075/0.015 mmol, 2 and 3a in 1.0 mL dry DCM were added into a solution of 1, 4, [PdCl(allyl)]2, 6b, aniline 5b and 100 mg 4 Å MS in 1.5 mL dry DCM via a syringe pump under a nitrogen atmosphere for 3 h, and the resulting mixture was stirred for another 1 h at −10 °C.
