Fig. 3: Landscape of multiregional non-malignant cells.

a UMAP of non-malignant cells colored by cell types. CAFs, cancer-associated fibroblasts; TAMs. tumor-associated macrophages; TECs, tumor-associated endothelial cells. b Violin plots of cell-type specific marker gene expression in non-malignant cells. c, d UMAP of non-malignant cells colored by tumor regions (c) and case IDs (d). e Correlation of T cells (n = 61,561) between different tumor regions of each individual case. In the box plots, the central rectangles span the first quartile to the third quartile, with the segments inside the rectangle corresponding to the median. Whiskers extend 1.5 times the interquartile range. Source data are provided as a Source data file.