Fig. 8: Schematic of sensory nerve niche regulating MSC homeostasis in adult mouse incisor.
From: Sensory nerve niche regulates mesenchymal stem cell homeostasis via FGF/mTOR/autophagy axis
Sensory nerve predominates in innervating the mouse incisor, which confers the mouse incisor as an ideal model for the study of the relationship between sensory nerves and MSCs. FGF1, a ligand secreted by sensory nerves, is enriched in the proximal mesenchymal end of the incisor and surrounding Gli1+ cell. FGF1 directly regulates MSCs in the incisor by binding to FGFR1 specifically and activates the FGF/p-JNK/mTOR/autophagy axis to regulate MSCs in maintaining tissue homeostasis.
