Fig. 6: Detection of cell-state-specific clonal impacts from genotyping-of-transcriptomes.
From: Decision level integration of unimodal and multimodal single cell data with scTriangulate
a Fish-plot displaying the clonal evolution of a patient with one (SF3B1), two (SF3B1-CALR), or three (SF3B1-CALR-NFE2) causal MPN mutations. GoT (arrow) indicates when single-cell profiling and genotyping were performed. b MPN single-cell clusters assigned by supervised assignment (cellHarmony) relative to healthy bone marrow CD34 + progenitors, with the clonal architecture of the cells indicated in the inset. c Sankey diagram of scTriangulate transcriptionally coherent cell populations, considering gene expression and clonal genotype. d Expression heatmap of final scTriangulate clusters for MEP, indicating the originally predicted genotypes from GoT and scTriangulate reassignments. Source data are provided as a Source Data file.
