Fig. 2: Mechanism of FSH-induced FSHR activation. | Nature Communications

Fig. 2: Mechanism of FSH-induced FSHR activation.

From: Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor

Fig. 2

a–d Structural comparison of the active and inactive FSHR. The overall structure (a), the extracellular side of TMD (b), the intracellular side of TMD (c, d). e The Schematic diagram of FSH-induced FSHR activation, the superposition of ECD structures of the active and inactive FSHR (left panel), and the activation conformation of FSHR (right panel), the clash of FSHβ with the membrane layer is marked with a red line and the extended hinge loop is shown in cyan. f Concentration-response curves for FSHR mutants at the extended hinge loop. The representative concentration-response curves from three independent experiments were shown. Data were shown as mean ± S.E.M. from three independent experiments. Source data are provided as a Source Data file.

Back to article page