Fig. 5: Comparison of ligand binding modes.
From: Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4)
a Conformations of different ligands during their insertion into the orthosteric pocket. The posture of INSL5 embedded in the membrane was compared with small molecules, galanin, GLP-1 and other peptides with N terminus, medium region and C terminus insertions into the TMD core. Receptor structures were omitted for clarity. b The interface area of peptide-receptor was measured with FreeSASA 2.0. Small molecules in grey; N termini insertions in red; medium region insertions in blue; C termini insertions in purple; galanin in brown; INSL5 in green and GLP-1 in cyan. Source data are provided as a Source Data file.
