Fig. 1: Single-cell analysis reveals the transcriptomic landscape in PDAC. | Nature Communications

Fig. 1: Single-cell analysis reveals the transcriptomic landscape in PDAC.

From: Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment

Fig. 1

A Clinicopathologic characteristics for each patient sample including treatment status, stage, Moffitt subtype, and procedure. EUS endoscopic ultrasound. B Workflow depicting sample acquisition, processing, and analysis. Designed with BioRender©. C UMAP, embedding of the expression profile of 139,446 cells that passed quality control from n = 27 patient samples. Distinct clusters are annotated and color-coded. CAF cancer-associated fibroblast, NK natural killer, UMAP uniform manifold approximation and projection. D Heatmap of the five most differentially expressed genes within each cluster. Colors correspond to the cluster colors in Fig. 1C. E Proportional distribution of each cell cluster by individual sample.

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