Fig. 4: Charting the T/NK landscape in the PDAC tumor microenvironment. | Nature Communications

Fig. 4: Charting the T/NK landscape in the PDAC tumor microenvironment.

From: Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment

Fig. 4

A UMAP overview of the T/NK compartment. NK natural killer, UMAP uniform manifold approximation and projection. B The most differentially expressed gene within each T/NK cluster. C UMAP of the more granular CD8 + T cell reclustering reveals additional subpopulations. D The most differentially expressed gene within each CD8 + T cell cluster. E Hierarchical clustering of the CD8 + T cell subsets based on dysfunction and cytotoxicity scores. F Composition of the CD8 + T cell subset (excluding the two non-T cell clusters and the single-patient cluster).

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