Fig. 4: Postprocessing analysis of single-cell RNA-seq datasets of mouse lung stromal retinoid-containing cells. | Nature Communications

Fig. 4: Postprocessing analysis of single-cell RNA-seq datasets of mouse lung stromal retinoid-containing cells.

From: Retinoids stored locally in the lung are required to attenuate the severity of acute lung injury in male mice

Fig. 4

a UMAP visualization of stromal cell clustering inferred from mouse lung retinoid-containing cell scRNA-seq datasets; Three retinoid-containing lipofibroblast clusters (proliferative, conventional, and myofibroblast-committed lipofibroblasts) are annotated. b Dot plot visualization of marker gene expression of lung fibroblasts (alveolar and adventitial, Col13+ and Col14+, lipofibroblasts, and myofibroblasts) in stromal clusters from retinoid-containing cell scRNA-seq datasets. The x-axis (Features) gives gene names, the y-axis (Identity) indicates cluster numbers. The level of expression is specified by the color legend. Size of the cell population expressing the gene of interest is indicated by the size of the circle as specified by the legend. c Dot plot visualization of differentially expressed genes (DEGs) in stromal clusters (proliferative, conventional, and myofibroblast-committed lipofibroblasts) from retinoid-containing cell scRNA-seq datasets. The x-axis (Features) indicates gene names, the y-axis (Identity) indicates cluster numbers. The intensity of expression is indicated by the color legend. Size of the cell population expressing the gene of interest is indicated by the size of the circle as specified in b and c.

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