Fig. 7: Loss- and gain-of-function mouse models for lung cell retinoid signaling during LPS-induced ALI. | Nature Communications

Fig. 7: Loss- and gain-of-function mouse models for lung cell retinoid signaling during LPS-induced ALI.

From: Retinoids stored locally in the lung are required to attenuate the severity of acute lung injury in male mice

Fig. 7

a Bronchoalveolar lavage (BAL) fluid cell numbers in EC-Rardn mice 24 h after intranasal instillation of LPS (5 mg/kg of body weight in PBS) or PBS alone. Values marked with different letters (a, b, c, d) are statistically different (a is different from b, p = 0.026; c is different from d, p = 0.043). Statistical differences were analyzed by a one-way ANOVA. All values are given as the mean ± 1 S.D., n = 6 for PBS group, n = 3 for LPS group. b Kaplan–Meier survival curves for EC-Rardn mice as well as for their respective littermate controls (Rardnfl/fl mice) over the 7-day period after intranasal instillation of a LPS (25 mg/kg of body weight in PBS) or PBS alone. Statistically significant differences (P = 0.044) were identified using the log rank test to compare survival curves for LPS-instilled EC-Rardn and Rardnfl/fl mice, n = 8 for each group. c Kaplan–Meier survival curves for Lrat−/− mice supplemented with 300 IU of retinol over the 7-day period after intranasal instillation of a LPS (25 mg/kg of body weight in PBS) or PBS alone, n = 14 for each group. P = 0.176 denotes the lack of statistically significant difference calculated using the log rank test comparing the survival curves for LPS-instilled Lrat+/+ and retinoid-supplemented Lrat−/− mice, n = 14 for each group.

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