Fig. 8: Schematic for the contribution of Egr-1 rhythm to the correlation between circadian rhythms and metabolic patterns with age increased. | Nature Communications

Fig. 8: Schematic for the contribution of Egr-1 rhythm to the correlation between circadian rhythms and metabolic patterns with age increased.

From: The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice

Fig. 8

At a young age, Egr-1 combines with circadian genes BMAL1/CLOCK to form a complex, then regulates the circadian expression of Cidea to maintain the balance of lipid metabolism. With age increased, Egr-1 rhythm alteration might result in uncoupling of Egr-1 with both circadian genes BMAL1/CLOCK and lipid metabolic genes Cidea, facilitating the CD36 expression to promote the fatty acid uptake, accelerating the amino acid uptake to form more fatty acid in hepatocytes, thus, leading to the decoupling of liver circadian and the lipid metabolic disorder in ageing mice. However, how the Egr-1 rhythm responds to the master clock remains to be explored. In the work model, the elements of young and old liver were bought from the website (https://www.dreamstime.com/illust ration-non-alcoholic-fatty-liver-disease-comparison-shows-healthy-diseased-image191689868).

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