Fig. 2: Distinct chromodomain protein-histone modification association maps on chromosome arms and centers.

a Heatmap showing percentage of chromodomain protein peaks covered by histone modifications in chromosome arms. (b–e) Heatmaps comparing heterochromatin-enriched histone modifications (H3K9me2, H3K9me3, H3K27me3) and euchromatin-enriched histone modifications (H3K4me3, H3K36me3, H3K79me3) with the indicated chromodomain proteins in chromosome arms. Each horizontal line shows a target of the indicated chromodomain protein. n, number of targets. Raw reads were normalized to bins per million mapped reads (BPM). The color scale shows the range of heatmap intensities. f A summary of the interaction of chromodomain proteins with histone modifications on chromosome arms. “Graded histone modification occupied” for a pair of chromodomain protein and histone modification fell into 3 categories: grade 3 = “prominent” (red), grade 2 = “detectable” (green), and grade 1 = “weak” (purple). See Methods for details. g Distribution of chromodomain protein ChIP-seq peaks on different genomic features (promoters, exons, introns, etc.) across distinct broad chromosome domains. h Bar plot showing the association of chromodomain proteins with repetitive elements across distinct broad chromosome domains on chromosomes.