Fig. 3: Recognition of ET-1 by ETAR.
From: Structural basis of peptide recognition and activation of endothelin receptors
a Sequence of ET-1. The N-terminal, α-helical, and C-terminal regions of ET-1 are colored blue, green, and yellow, respectively. b Cross-section of the ET-1-binding pocket in ETAR. Two pairs of intramolecular disulfide bonds of ET-1 are displayed as sticks. ET-1 is shown as a ribbon model with its three regions colored as in a. c, d Detailed interactions between ET-1 and ETAR at the C-terminal region. H-bonds are shown as blue dotted lines. e The profile of the interaction residues between the C-terminal region of ligand and endothelin receptors. f Detailed interactions between ET-1 and ETAR at the α-helical region.
