Fig. 1: Structural organization of HA antigens in influenza vaccines. | Nature Communications

Fig. 1: Structural organization of HA antigens in influenza vaccines.

From: Commercial influenza vaccines vary in HA-complex structure and in induction of cross-reactive HA antibodies

Fig. 1

a Images from negative-stain EM of Fluzone HD vaccine and b select 2D classes averages. Similarly, images and class averages for c, d Flucelvax, e, f Flublok, and g, h Fluad. Complexes observed include HA starfish-like complexes (black arrows), isolated molecules (white arrows), large round complexes (white asterisk), RNP (black asterisk) and small round mostly bald particles (bracket, putative micelles). Scale bars are 100 nm for panels a, c, e, and g, and 10 nm for panels b, d, f, h. Grids representing each vaccine were prepared at least three times, to account for staining variation.

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