Table 2 Models depicting the association of leukocyte telomere length (LTL) with age and mortality across diverse racial populations

From: Telomere length associates with chronological age and mortality across racially diverse pulmonary fibrosis cohorts

Characteristics

White

Black

Hispanic

Asian

Combined

Regression models for Age*

Unadjusted LTL

     

PF Cohort

(n = 1613)

(n = 162)

(n = 187)

(n = 70)

(n = 2046)

    All, R (Root MSE)

−0.21 (0.27)

−0.29 (0.24)

−0.39 (0.28)

−0.17 (0.29)

−0.30 (0.28)

    95% CI

−0.26 to −0.17

−0.43 to −0.14

−0.51 to −0.26

−0.40 to 0.07+

−0.33 to −0.26

  HRS Cohort

(n = 4319)

(n = 779)

(n = 614)

(n = 96)

(n = 5808)

    All, R (Root MSE)

−0.04 (0.65)

−0.02 (1.11)

−0.12 (0.59)

−0.07 (0.63)

−0.05 (0.73)

    95% CI

−0.07 to −0.01

−0.10 to −0.05

−0.42 to −0.05

−0.26 to −0.14

−0.08 to −0.03

Standardized LTL**

PF cohort

(n = 1613)

(n = 162)

(n = 187)

(n = 70)

(n = 2046)

    All, R (Root MSE)

−0.22 (1.08)

−0.33 (0.96)

−0.31 (1.07)

−0.14 (1.10)

−0.28 (1.08)

    95% CI

−0.27 to −0.17

−0.46 to −0.18

−0.44 to −0.18

−0.36 to 0.10+

−0.32 to −0.24

HRS cohort

(n = 4319)

(n = 779)

(n = 614)

(n = 96)

(n = 5808)

    All, R (Root MSE)

−0.13 (1.09)

−0.15 (1.10)

−0.29 (1.09)

−0.35 (1.09)

−0.17 (1.10)

    95% CI

−0.16 to −0.10

−0.22 to −0.09

−0.36 to −0.21

−0.51 to −0.16

−0.19 to −0.14

PF mortality risk models

(n = 1613)

(n = 162)

(n = 187)

(n = 70)

(n = 2046)

#Overall crude mortality rate

8.92

5.27

9.62

6.62

8.49

    (95% CI)

(8.16–9.76)

(3.91–7.10)

(7.47–12.38)

(3.84–11.40)

(7.83–9.20)

+Mortality incidence rate ratio, TL50

2.10

2.09

2.79

2.67

2.31

    (95% CI)

(1.71–2.59)

(1.07–4.07)

(1.66–4.69)

(0.89–8.03)

(1.93–2.78)

*Mortality hazard ratio for TL50

2.21

2.22

3.40

2.11

2.47

    (95% CI)

(1.79–2.72)

(1.05–4.66)

(1.88–6.14)

(0.54–8.23)

(2.05–2.97)

  1. R Pearson’s bivariate correlation coefficient. Root MSE root mean squared error. PF pulmonary fibrosis. HRS health retirement survey.
  2. *Hazard Ratio for TL50 in multivariable Cox regression models adjusting for forced vital capacity, diffusing capacity of the lungs for carbon monoxide, interstitial lung disease subtype, and hospital center. For multivariable models, White n = 1534, Black n = 145, Hispanic n = 175, Asian n = 64, All (including patients with race categorized as other, n = 14) n = 1932.*P <  0.001 for all regression models except where denoted by +. **Standardized telomere lengths in quartiles.
  3. #Overall crude mortality rate computed per 100 person-yrs. #P value for Mantel–Haenszel test statistic.
  4. +Mortality incidence rate ratios in subjects with age- and gender-adjusted leukocyte telomere length below the median (TL50) were estimated using a generalized linear model with a Poisson distribution and logistic regression link adjusting for age, gender, forced vital capacity, diffusing capacity of the lungs for carbon monoxide, and hospital center.
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