Fig. 4: RNA-seq to assess global serum exposure impacts on the transcriptome.
From: Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria
A UpSet plot representing the shared and distinctive transcriptional responses across strains of the same species. Only genes with significant differential expression after exposure to human serum are represented (FDR < 0.05; |log2 fold change | >1). Horizontal bars indicate the total number of significant changes per strain (top: up in serum, bottom: down in serum). Vertical bars represent the number of shared up/down genes across strains. Overlapping responses (intersections) are defined below the bars with connected dots. Darker blue bars represent intersections with higher numbers of strains and black bars the distinctive response for each strain. B Multidimensional scaling plots of the transcriptional responses of core genes across strains of the same species. Point shapes represent different strains and each point corresponds to an individual biological replicate. The colour of the points and ellipses differentiate cultured in RPMI from serum-exposed samples.
