Fig. 4: AJSZ regulate chromatin accessibility dynamics during cell fate reprogramming. | Nature Communications

Fig. 4: AJSZ regulate chromatin accessibility dynamics during cell fate reprogramming.

From: Conserved transcription factors promote cell fate stability and restrict reprogramming potential in differentiated cells

Fig. 4

a, b t-SNE visualization of cell clusters after scATAC-seq of siControl-transfected HDFs 2 days after MGT overexpression (a), or siAJSZ-transfected HDFs 2 days after MGT overexpression (b). c GO term analysis for genes with differential accessibility transcriptional start sites (TSS) in cluster 2 vs remaining 8 clusters. d Topological mapping of domains 1 and 2 in regard to their chromosomal ___location. e Size distribution of differentially accessible chromatin regions in domains 1 and 2. f Most differentially enriched TF motifs in ___domain 1 as compared to 2 and conversely. g, h AJSZ binding density in ___domain 1 (g) and 2 (h) at ground state in HDFs. i Model summarizing the role of AJSZ in the regulation of chromatin accessibility during cell fate reprogramming.

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