Fig. 5: AJSZ proximally regulates gene expression during cell fate reprogramming. | Nature Communications

Fig. 5: AJSZ proximally regulates gene expression during cell fate reprogramming.

From: Conserved transcription factors promote cell fate stability and restrict reprogramming potential in differentiated cells

Fig. 5

a Heatmap of differentially expressed (DE) genes in siControl- and siAJSZ-transfected HDFs 2 days after MGT overexpression b Venn diagram showing the overlap between DE and core promoter-bound (−1 kb-TSS- +0.1 kb) genes. 460 genes were both DE and bound by AJSZ at core promoter regions, including 348 downregulated and 112 upregulated genes. c Bar charts showing top-ranked biological terms enriched for the 460 DE and core promoter-bound genes. d Breakdown of the percentage of DE and core promoter-bound genes containing ATF7IP, JUNB, SP7, or ZNF207 binding sites. e ChIP-seq tracks for JUNB binding sites. f, g Genome browser views showing JUNB binding at TAGLN (f) and at MEF2C core promoter regions (g) in HDFs.

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