Fig. 1: Representative macrolide biosynthetic pathways. | Nature Communications

Fig. 1: Representative macrolide biosynthetic pathways.

From: Unnatural activities and mechanistic insights of cytochrome P450 PikC gained from site-specific mutagenesis by non-canonical amino acids

Fig. 1

a The late pikromycin/(neo)methymycin biosynthetic pathway in which the glycosyltransferase-mediated sugar attachment precedes the P450-catalyzed hydroxylation. b The partial avermectin biosynthetic pathway with an order of oxidation-glycosylation. c The post-PKS pathway of mycinamicin biosynthesis with staggered monooxygenation and glycosylation steps. The functional groups introduced by P450 are highlighted in red, and the functional groups introduced by glycosyltransferase are highlighted in blue.

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