Fig. 3: Loss of Mrps5 alters translational and metabolic programs in the heart.
From: A defect in mitochondrial protein translation influences mitonuclear communication in the heart
a Volcano plot of dysregulated transcripts in Mrps5cKO hearts by comparison with Mrps5fl/fl hearts at 12 weeks following tamoxifen injection. b Hierarchical clustering heatmap of dysregulated transcripts in Mrps5cKO hearts. n = 3. c Principal component analysis (PCA) of gene expression in Mrps5fl/fl and Mrps5cKO hearts. n = 3. d Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analysis of downregulated genes in Mrps5cKO hearts. e KEGG functional enrichment analysis of the upregulated genes in Mrps5cKO hearts. f Gene set enrichment analysis (GSEA) showing dysregulated signaling pathways in Mrps5cKO hearts. g Enrichment plots of key pathways in Mrps5cKO hearts. h Heatmaps of the relative expression of the differentially expressed genes in dysregulated pathways identified in Mrps5cKO hearts. P values were determined by two-tailed unpaired Students’ t-test in (a, d, e).
