Fig. 1: The multi-omics landscape in ESCC progression.
From: Integrative proteogenomic characterization of early esophageal cancer
a Overview of the experimental design and the number of samples for the genomic, proteomic, and phosphoproteomic analyses. ESCC esophageal squamous cell carcinoma. b The genomic profile of ESCC progression. Top: the mutation number and types of all the samples from early to progressive ESCC. Bottom: the somatic copy number alterations of all the samples from early to progressive ESCC. The mutation frequencies are shown by a bar plot at the right panel. NT phase: non-tumor phase, IEN phase: intraepithelial neoplasia phase, A-ESCC phase: advanced-stage ESCC phase. c The gain of neo-mutations at all stages in ESCC progression. d Analysis of the mutations loads of diverse cohorts. EESCC cohort: early ESCC cohort. e The number of the identified proteins of 786 samples (Kruskal–Wallis test, p < 2.2E–16). f Boxplot showing the number of the phosphosites identifications of 145 samples (Kruskal–Wallis test). Boxplot shows median (central line), upper and lower quartiles (box limits), 1.5× interquartile range (whiskers). ****p < 1.0E–4, ***p < 1.0E–3, **p < 0.01, *p < 0.05, ns. > 0.05. Source data are provided as a Source data file.
