Fig. 1: SARS-CoV-2-specific T cell responses in peripheral blood from convalescent and vaccinated patients. | Nature Communications

Fig. 1: SARS-CoV-2-specific T cell responses in peripheral blood from convalescent and vaccinated patients.

From: Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection

Fig. 1

a Schematic overview of patients included in this study and characteristics of the study groups. b Representative flow-cytometry plots showing CD4+ T cells expressing CD107a and IFNγ after exposure of whole PBMCs to S-peptide pools or left unstimulated for each of the four groups included in this study (complete gating strategy is shown in Supplementary Fig. 2a). c Comparison of the net frequency (background subtracted) of IFNγ+ cells within CD4+ (upper) and CD8+ (lower) T cell subsets after stimulation of PBMCs with any of the three viral peptide pools (membrane (M), nucleocapsid (N), and spike (S) peptides). Data were shown as median ± IQR, where each dot represents an individual patient for each group (Ctrl, control, n = 5; Inf convalescent infected, n = 9; LT vaccine 2/3 doses, n = 10, and ST, vaccine 3/4 doses, n = 6). Statistical significance was determined by Kruskal–Wallis test (with Dunn’s post-test, two-sided). Source data are provided as a Source Data file.

Back to article page