Fig. 6: Frequency of polyfunctional T cell responses against spike with a tissue-resident phenotype in the lung. | Nature Communications

Fig. 6: Frequency of polyfunctional T cell responses against spike with a tissue-resident phenotype in the lung.

From: Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection

Fig. 6

Comparison of the net frequency of S-specific polyfunctional CD107a+ IFNγ+ cells within lung CD4+ (upper) and CD8+ (lower) (non-) tissue-resident cell subsets (CD69- non-TRM, CD69+ TRM, and CD69+CD103+ TRM cells) for each of the four patient groups after exposure of single-cell lung suspensions to S-peptide pools. Data in bar graphs are shown as median ± IQR, where each dot represents an individual patient for each group (Ctrl, control, n = 5; Inf, convalescent infected, n = 8; LT, vaccine 2/3 doses, n = 10, and ST, vaccine 3/4 doses, n = 5). Statistical significance was determined by Kruskal–Wallis test (with Dunn´s post-test, two-sided) for the difference between the groups. Source data are provided as a Source Data file.

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