Fig. 3: Organisation and distribution of p893816-like plasmids.

a Organisation of p893816-like plasmids. The lengths and directions of transcription of various genes are shown as arrows. The upper track shows the resistance region. AMR genes indicated by solid red arrows, with resistance-related genes outlined in red. The boxes around dfrA17 and aadA5 represent the gene cassettes that carry these genes. Block arrows in white indicate various insertion sequences (IS), named/numbered as labelled, and the direction of their transposase gene. Fragments of different transposons (Tn) are shown as interrupted blocks in different colours (blue, purple, orange) and labelled by name, and a class 1 integron is also shown in grey and labelled. The lower track shows the plasmid backbone, with the AMR region insertion site indicated by dashed lines. Replication genes are in pink, conjugation genes in purple (tra) and grey (trb), toxin-antitoxin systems in blue, other genes encoding known plasmid functions in cyan and genes encoding hypothetical proteins in white. b The distribution of p893816-like plasmids. Number of draft genome assemblies in the 661 K COBS data structure showing k-mer similarity (≥0.80) to p893916, coloured by species and sequence type according to the inlaid keys. ST that are represented 10 or more times are named, while rare sequence types are collapsed into the category of ‘other’ within the respective species.