Fig. 3: Imaging and quantification of viral infection revealed a shift in infected regions shaped by the IFN-I response.
From: Type I interferon shapes brain distribution and tropism of tick-borne flavivirus
a Axial and coronal representation of the OCUM brain template with its according atlas21. b Typical example of an OPT-OCUM fusion displaying signal in the fourth ventricle (upper panel) and the VOI delineation based on the OCUM-atlas (lower panel). c Quantification and statistical analysis (two-tailed unpaired t-test) of viral OPT signal in fourth ventricle of WT and Ifnar–/– mice. All values were normalized to the mock group and are expressed in arbitrary units (A.U.). ***p = 0.002. d Anatomical mapping of infected cortical and olfactory bulb after coregistration of viral OPT signal (red) with OCUM brain template (grey). Images of WT and Ifnar–/– infected brains are shown in two representative axial plains. e–l Quantification and statistical analysis (two-tailed unpaired t-test) of viral OPT signal in representative VOIs or composite ROIs. For: e *p = 0.033, f ***p = 0.003, g ***p = 0.002, h *p = 0.016, i ****p = 0.001, j *p = 0.037, k *p = 0.037, l *p = 0.015. Source data are provided as a Source Data file.
