Fig. 1: A workflow of a genome-wide CRISPR-Cas9 knockout screen for AMA toxicity.
From: Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity
a Chemical structure of AMA. b HAP1 cells were treated with vehicle or different concentrations of AMA for 72 h, and cell viability was determined by CCK8 assays (n = 3 biological replicates). Data are presented as mean ± SD and are representative of three independent experiments. c The workflow of genome-wide CRISPR loss-of-function screening. Source data are provided as a Source Data file.
