Fig. 9: Identification of ICG as a STT3B inhibitor against mushroom AMA cytotoxicity.
From: Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity
A genome-wide CRISPR screen against mushroom AMA cytotoxicity has identified STT3B, a key enzyme in the N-glycan biosynthesis pathway, as a druggable target for preventing AMA-induced cell death. After an in silico drug screen with an FDA-approved library, ICG was identified as a specific inhibitor for STT3B. Eventually, ICG could effectively block AMA cytotoxicity in vitro and in vivo.
