Fig. 3: S-specific IgG responses in ChulaCov19 immunized mice.
a Kinetics of total IgG at 2 weeks after receiving 1 or 2 doses of 0.2, 1, 10, and 30 µg of ChulaCov19. b S-specific IgG2a/IgG1 ratio measured at 2 weeks after the 2nd dose. Note; the IgG2a/IgG1 ratio of 10 µg and 30 µg immunized mice were not analyzed due to limited volume of serum samples. The mid-point titers were determined in duplicate assays from 5 mice in each group. Bars (a) or horizontal lines (b) represent the geometric mean (GMT) for each group while error bars indicate the 95% confident interval. Each dot represents an individual animal. Statistical analysis significance was determined by two-sided Mann–Whitney test. Differences were considered significant at p < 0.05 with exact p-values shown. p < 0.05 and p < 0.01 are indicated by * and **, respectively. Source data are provided as a Source Data file.
