Fig. 6: Immune response and protective efficacy results in the challenge study. | Nature Communications

Fig. 6: Immune response and protective efficacy results in the challenge study.

From: Immunogenicity and protective efficacy of SARS-CoV-2 mRNA vaccine encoding secreted non-stabilized spike in female mice

Fig. 6

a Kinetic response of micro-VNT50 titer after ChulaCov19 immunization and after challenge. The titers were determined in duplicate assays from control (n = 5) or vaccinated groups (n = 6), respectively. Data are presented as GMT of micro-VNT50 titer with 95% confident interval. Statistical analysis was performed to compare the GMT of micro-VNT50 between 1 and 10 μg dosed mice at each time point. b Body-weight values with SD are presented as a percentage of initial body weight before challenge (Day 0) through Day 6 post-challenge. In the control group, 3 out of 5 mice reached euthanasia criteria on Day 5 hence only 2 mice were analyzed for body weight on Day 6 after challenge. c SARS-CoV-2 viral RNA copies with SD detected by RT-qPCR in serum and homogenized tissues of challenged animals analyzed at euthanasia date (Day 6). Each dot represents an individual animal. Note: tissues from 3/5 animals in control group were collected at day 5. RNA copies were calculated as genomic equivalent/mg of tissue. Statistical significance was determined by two-sided Mann–Whitney test. p < 0.05 and p < 0.01 are indicated by * and **, respectively. SD; standard deviation. Source data are provided as a Source Data file.

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