Fig. 4: Direction of QTL effects and associations between expression and methylation for co-localized eGene-meCpG pairs. | Nature Communications

Fig. 4: Direction of QTL effects and associations between expression and methylation for co-localized eGene-meCpG pairs.

From: meQTL mapping in the GENOA study reveals genetic determinants of DNA methylation in African Americans

Fig. 4

Results for 4854 eGene-meCpG pairs tested for colocalization using a p12 value of 6.3e−04 are presented. Results are stratified according to promoter region and non-promoter region, as well as posterior probability for a shared eSNP in the pairs greater than 0.8, 0.9, 0.95, 0.99, and 0.999. a, b Histograms of the percentage of eGene-meCpG pairs for which the direction of association between gene expression and DNA methylation is positive or negative in promoter region (a) or non-promoter region (b). c, d Histograms of the percentage of eGene-meCpG pairs showing the same or different direction of association in promoter region (c) or non-promoter region (d).

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