Fig. 5: Mediation analyses provide evidence for shared regulatory mechanisms. | Nature Communications

Fig. 5: Mediation analyses provide evidence for shared regulatory mechanisms.

From: meQTL mapping in the GENOA study reveals genetic determinants of DNA methylation in African Americans

Fig. 5

Results for two-sided Sobel test on 2246 potentially co-localized eGene-meCpG pairs identified using a p12 value 6.3e−04 are presented. a, b Histograms of two-sided Sobel test p-values for SEM (a) and SME (b). c, d Histograms of mediation proportion in significant SEM (c) and SME (d) (FDR < 0.05) two-sided Sobel tests. Blue vertical line: mediation proportion is 0; red vertical line: median mediation proportion. e Mediation analysis results for both the SME (red) and SEM (blue) two-sided Sobel tests. SME: SNP-Methylation-Expression direction; SEM: SNP-Expression-Methylation direction.

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