Fig. 5: Impact of identified biomarkers on apoptosis (a–c) (n = 4 replicates from four independent mouse islet preparations; 16 mice per preparation) or proliferation (n = 4 individual donors for human islets) (d) in mouse or human islets as indicated. | Nature Communications

Fig. 5: Impact of identified biomarkers on apoptosis (a–c) (n = 4 replicates from four independent mouse islet preparations; 16 mice per preparation) or proliferation (n = 4 individual donors for human islets) (d) in mouse or human islets as indicated.

From: Identification of biomarkers for glycaemic deterioration in type 2 diabetes

Fig. 5

Test compounds were added at 100 nM unless otherwise indicated. a ***p < 2.2·10-16 for the effects of NogoR vs vehicle and ***p = 5.45·10-8 for the effects of IL18Ra vs vehicle; b *p = 0.0196, 0.0117 for the effects of 3 nM and 10 nM NogoR, respectively versus vehicle by one-way ANOVA; ***p = 1.67·10-6 and p < 2.2·10-16 for the effects of 30 and 100 nM NogoR, respectively. c ***p = 0.0009; d ***p = 0.0015. The DYRK1A/DYRK2/CLK kinase inhibitor leucettine L4186 was used as a positive control. Error bars represent means ± S.D. See Methods for other details. Source data are provided as a Source Data file.

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