Fig. 6: SMARCB1 retargets SWI/SNF complexes to enhancers bearing TFCP2L1 motifs. | Nature Communications

Fig. 6: SMARCB1 retargets SWI/SNF complexes to enhancers bearing TFCP2L1 motifs.

From: SMARCB1 regulates a TFCP2L1-MYC transcriptional switch promoting renal medullary carcinoma transformation and ferroptosis resistance

Fig. 6

a Read density maps showing genome localization BRG1 (G) and H3K27ac (K) in RMC2C cells expressing either SMARCB1 or mCHERRY using as a reference all merged H3K27ac sites (1st panel), all TSS-proximal H3K27ac sites (3rd panel) and all TSS-distal H3K27ac sites (4th panel). Expression changes for genes associated with BRG1/H3K27ac- clusters following SMARCB1 re-expression are shown in the 2nd panel. b RSAT-based motif enrichment analysis using A3 sites ranked by number of sites. c Ontology analysis of genes associated with A3 as annotated by GREAT. d Read density maps showing genome localization of BRG1 (G), H3K27ac (K) and MYC (M) in RMC2C cells expressing either SMARCB1 or mCHERRY using as a reference all merged MYC sites (1st panel), all TSS-proximal MYC sites (2nd panel) and all TSS-distal MYC sites (3rd panel). e RSAT-based motif enrichment analysis using one thousand best MYC peaks ranked (by peak score). f Working model of the oncogenic and SMARCB1 tumour-suppressor events in RMC. Created with BioRender.com.

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