Fig. 1: Phenotype-haplogroup association results in 263,883 unrelated white British samples in UK Biobank.
From: The contributions of mitochondrial and nuclear mitochondrial genetic variation to neuroticism
Counts pertains to the number of individuals that belong to each haplogroup (HG). Model 1, compares the mean of each group to the mean of the reference group. Haplogroup H and super haplogroup HV were used as the reference groups in haplogroup association analysis and super haplogroup association analysis, respectively. Model 2, compares the mean of each haplogroup/super haplogroup to the mean of those from outside that grouping. The rows labelled combined illustrates the association with the three neuroticism phenotypes following the combining of relevant haplogroups and the testing of the super haplogroup. Group ‘Other’ was not tested in model 2 as it was a mixture of haplogroups and was not of interest. Error bars show the 95% confidence interval. The significance threshold (red dotted line) for the ten common haplogroups was 0.05/10. For the super haplogroups, we considered them to be associated with the neuroticism phenotypes if the P value (two-sided t test) of super haplogroup analysis was lower than the threshold of 0.05/10 and lower than any of their contributing haplogroups.
