Fig. 1: The workflow of the REST method for restoring signal.
From: A method for restoring signals and revealing individual macromolecule states in cryo-ET, REST

A Strategy 1 consists of generating the training pairs using subtomogram averaging (STA), training the model and restoring information. B Strategy 2 consists of generating the training pairs using simulated data, training the model and restoring information. The noise volume images appear distorted. The clean volume images have no distortion with high SNR.