Fig. 6: REST could directly improve the interpretation of nucleosome in vivo.
From: A method for restoring signals and revealing individual macromolecule states in cryo-ET, REST
A Tomographic slice of frog erythrocyte nuclei thinned by cryo-FIB. B 3D REST-restored view of the tomographic data in A. Yellow circle labelled the particle displayed in C. C The densities of nucleosome which were directly extracted from REST-restored tomogram. D The different conformation of subtomogram averaged map calculated from the same sample. Nucleosomes without (pink) or with linker DNA (cyan), and other non-classic nucleosome-like densities (grey) are coloured differently in B–D.
