Fig. 5: Cognitive testing result, and integrative analysis of the measured vascular properties.

a NOL test scores tracked by individual animals (gray lines; 7 AD mice and 6 WT mice, 9 time points) and their LME fits (color line, mean; color shade, 95% CI). b The LME fits shown together (line, mean; shade, 95% CI). c Chronological graph of all vascular properties whose fractional changes became significantly different between AD and WT mice during the ages of measurement. The graph displays their rates of change in AD at their AOS (structural properties in purple, and flow properties in green). d Significant correlations between the NOL discrimination index and the vascular alterations (p < 0.05, Wald test, no multiple comparison correction was used; see “Methods” for details). Pairs with positive and negative correlations are shown in red and blue respectively. More opaque lines indicate higher maximum correlation, and thinner lines means that the maximum correlation appeared at longer age lags. A correlation with an age lag means that one alteration was correlated to the other one with a certain time delay. Two examples of significant correlations are presented on the right, where each circle represents a measurement from a single animal at a single age point, and the orange line and shade depict the fitted line (mean) and its 95% CI. Source data are provided as a Source Data file.