Table 1 Summary of statistical results of 25 vascular properties

From: Near-lifespan longitudinal tracking of brain microvascular morphology, topology, and flow in male mice

Property

Rate of change with age (RCA) in AD (%/month)

RCA in WT (%/month)

P value of difference in RCA between AD and WT

The age of significance (weeks)

Pial vessel diameter

−1.3 (−2.4 to −0.2)

−1.1 (−2.2 to 0.0)

0.78

 

Arteriolar diameter

−13.2 (−17.5 to −8.7)

−7.2 (−11.4 to −2.8)

0.008

18

Venular diameter

−13.1 (−18.0 to −7.8)

1.3 (0.9–1.7)

p = 2.4e−8

12

Penetrating vessel density

−5.7 (−10.8 to −0.6)

−1.3 (−6.7 to 4.7)

p = 0.11

 

Arteriolar flow

−12.9 (−18.7 to −7.3)

−9.6 (−19.4 to −0.6)

p = 1.4e−6

21

Venular flow

−16.3 (−24.9 to −7.9)

−0.8 (−2.9 to 1.3)

0.009

18

Capillary length

−1.5 (−2.6 to −0.3)

0.2 (−1.0 to 1.3)

0.005

25

Capillary length COV

−0.2 (−1.0 to 0.7)

0.1 (−0.9 to 1.1)

0.56

 

Capillary diameter

0.2 (−0.4 to 0.9)

0.0 (−0.8 to 0.9)

0.63

 

Capillary diameter COV

0.3 (−0.7 to 1.3)

0.5 (−0.3 to 1.3)

0.60

 

Capillary tortuosity

2.2 (1.3–3.1)

0.7 (−0.5 to 1.9)

0.015

>35

Capillary tortuosity COV

1.0 (−0.1 to 2.1)

3.4 (−3.5 to 10.4)

0.60

 

Branching order

0.9 (−0.6 to 2.4)

1.4 (0.3–2.5)

0.22

 

Branching order COV

1.3 (0.4–2.3)

1.0 (0.2–1.9)

0.49

 

Betweenness

3.9 (1.3–5.8)

−0.7 (−2.8 to 1.5)

p = 0.0003

21

Betweenness COV

−1.7 (−3.2 to −0.2)

−0.9 (2.2–0.4)

0.21

 

Closeness

−1.6 (−3.8 to 0.6)

−1.1 (−3.2 1.0)

0.67

 

Closeness COV

−3.0 (−7.9 to −2.0)

3.6 (0.9–6.4)

p = 7.8e−6

18

Shortest cycle

1.9 (0.3–3.4)

−0.4 (−1.7 to 0.8)

p = 0.0006

20

Shortest cycle COV

−0.7 (−2.2 to 0.7)

−1.3 (2.6 to −0.0)

0.37

 

Capillary number density

0 (−0.9 to 1.0)

0.0 (0.0–0.0)

0.23

 

Capillary length density

0.6 (−0.6 to 1.9)

0.8 (−0.7 to 2.4)

0.79

 

Fractal dimension

0.1 (−0.4 to 0.3)

−0.1 (−0.5 to 0.2)

0.66

 

RBC flux

6.0 (3.0–9.0)

2.1 (0.9–3.2)

p = 3.7e−9

22

RBC flux COV

−6.7 (−11.4 to −2.1)

−3.0 (−4.7 to −1.4)

p = 2.0e−5

23

  1. The two numbers in the parenthesis present 95% CI. See “Methods” for how the rate of changes with age (RCA) was defined when the fractional change of a property was better fit with the sigmoid function.
  2. Shown in bold are those that showed significant differences between AD and WT before the latest age of measurement (35 WOA, significance tested with α = 0.05 after Benjamini–Hochberg correction; p values were obtained using a Wald test).
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