Fig. 6: Speed elevation is inhibited by dopamine in fed animals at 25 °C and by glutamate signaling in starved animals at 15 °C. | Nature Communications

Fig. 6: Speed elevation is inhibited by dopamine in fed animals at 25 °C and by glutamate signaling in starved animals at 15 °C.

From: Multisite regulation integrates multimodal context in sensory circuits to control persistent behavioral states in C. elegans

Fig. 6

Impact of a cat-2 mutation blocking dopamine biosynthesis (a–d) on the speed of fed animals at 15 or 25 °C (a), and on the long-lasting speed response evoked by a 5-min optogenetic activation of FLP in animal maintained at 25 °C (b–d scored and reported as in Fig. 5). Similar analyses for an eat-4 mutation affecting glutamatergic signaling in starved animals at 15 °C (blue) or 25 °C (orange) (e–h). Data as mean ± s.e.m.; indicated n correspond to independent assays, each scoring ≥30 animals (a–h) *p < 0.05 and **p < 0.01 versus 15 °C Fed condition or respective N2 control; #p < 0.05 and ##, p < 0.01 versus the indicated condition by Bonferroni posthoc tests. ns not significant. Source data are provided as a Source Data file.

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