Fig. 8: Multi-site regulation in the FLP pathway controls speed elevation during glocal search. | Nature Communications

Fig. 8: Multi-site regulation in the FLP pathway controls speed elevation during glocal search.

From: Multisite regulation integrates multimodal context in sensory circuits to control persistent behavioral states in C. elegans

Fig. 8

Model for food and temperature-dependent control of exploitation/exploration strategies via multi-site gating mechanisms (traffic lights). On food, animals dwell regardless of temperature with one or more gates closed in the FLP-pathway (red lights). During global search after starvation at 15 °C, only parts of the gates are lifted (green lights), still preventing the up-regulation of speed, which is also hindered by FLP glutamate signaling. After starvation at 25 °C, all gates are lifted and FLP tonically signals via FLP-5/DMSR-1 to elevate speed and promote glocal search.

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