Fig. 3: Substrate scope with respect to oxime esters.
From: Copper-catalyzed asymmetric C(sp3)-H cyanoalkylation of glycine derivatives and peptides
Standard conditions: 1b (0.1 mmol), 2 (2.0 equiv), Cu(MeCN)4PF6 (10 mol%), L2 (15 mol%), DABCO (2.0 equiv), acetone (0.5 mL), 0 °C, 18 h, argon atmosphere. Isolated yields based on 1b after chromatographic purification. Ee was determined by chiral HPLC. D.r. (diastereo ratio) was determined by 1H NMR analysis.
