Fig. 4: Substrate scope with respect to glycine derivatives and peptides.
From: Copper-catalyzed asymmetric C(sp3)-H cyanoalkylation of glycine derivatives and peptides
Standard conditions: 1 (0.1 mmol), 2 (2.0 equiv), Cu(MeCN)4PF6 (10 mol%), L2 (15 mol%), DABCO (2.0 equiv), acetone (0.5 mL), 0 °C, 18 h, under Ar. Isolated yields based on 1 after chromatographic purification. Ee was determined by chiral HPLC. D.r. was determined by 1H NMR analysis. aDMF (0.5 mL) as solvent, 36 h. A Substrate scope with respect to glycine derivatives and dipeptides. B Substrate scope with respect to peptides.
