Fig. 4: SELENOP concentrations are positively correlated with serum copper.
From: Excessive copper impairs intrahepatocyte trafficking and secretion of selenoprotein P
a Serum ceruloplasmin (CP) concentrations of Wilson’s patients at time point of diagnosis measured by ELISA. Serum CP oxidase (CPO) activity (b), total copper (c), free copper (d), SELENOP (e), and selenium (f) concentrations of Wilson’s patients measured using photometric activity, TXRF with 1 mg/L gallium as standard element for 1000 s or a fluorometric method (normal CP n = 8; low CP n = 11; diseased n = 4). Data are depicted as mean ± SD. Biological replicates are indicated by individual dots. Statistical analyses were based on one-way ANOVA with Bonferroni’s post-test. *p < 0.05; **p < 0.01; ***p < 0.001 vs. ‘normal CP’, #p < 0.05; ##p < 0.01 vs. ‘low CP’. g Results from EPIC-Potsdam samples for SNP rs11708215 (coded per G allele) and its correlation with serum SELENOP from linear regression using an additive genetic model adjusted for age at recruitment and sex. Serum SELENOP levels were natural log-transformed and standardized. Source data are provided as a source Data file.
