Table 1 Loci reported for HF in the meta-analysis of HERMES and MVP HF GWAS datasets

rsID

Chr

Pos

Nearest Gene

PoPs gene

CADD Phred Score

NEA

EA

MAF

Beta

SE

P value

rs4755720

11

43628749

HSD17B12

HSD17B12

7.526

C

T

0.400

−0.037

0.006

8.14E-11

rs7766436

6

22598259

HDGFL1

HDGFL1

1.902

C

T

0.286

0.037

0.006

5.18E-10

rs3820888

2

201180023

SPATS2L

SPATS2L

6.261

C

T

0.378

−0.034

0.006

1.20E-09

rs12992672

2

632592

TMEM18

TMEM18

1.061

G

A

0.172

0.045

0.007

1.70E-09

rs10846742

12

125308682

SCARB1

UBC

0.277

G

A

0.173

−0.046

0.008

1.73E-09

rs17620390

4

114384328

CAMK2D

CAMK2D

1.907

C

A

0.284

−0.037

0.006

1.90E-09

rs72688573

1

50746997

FAF1

FAF1

6.834

C

T

0.022

−0.122

0.021

4.31E-09

rs10938398

4

45186139

GNPDA2

N/A

1.094

G

A

0.421

0.033

0.006

4.50E-09

rs6945340

7

75100124

POM121C

HIP1

3.58

C

T

0.208

−0.040

0.007

5.89E-09

rs7564469

2

145258445

ZEB2

GTDC1

19.56

C

T

0.165

−0.043

0.007

6.66E-09

rs7977247

12

107259470

RIC8B

RFX4

1.868

C

T

0.434

0.032

0.006

1.07E-08

rs1016287

2

59305625

FANCL

N/A

19.22

C

T

0.280

0.037

0.006

1.11E-08

rs959388

14

30169987

PRKD1

PRKD1

0.596

G

T

0.417

−0.031

0.006

1.30E-08

rs233806

4

103212846

SLC39A8

BANK1

9.713

C

T

0.207

−0.037

0.007

1.57E-08

rs17038861

2

37233265

HEATR5B

PRKD3

0.403

G

T

0.195

0.039

0.007

2.35E-08

rs9352691

6

79785607

PHIP

PHIP

6.373

C

T

0.365

0.032

0.006

2.65E-08

rs10520390

19

46327831

SYMPK

DMWD

2.849

G

C

0.059

0.074

0.013

2.87E-08

rs79682748

1

66989719

SGIP1

SGIP1

4.719

G

A

0.018

−0.155

0.028

3.00E-08

rs7859727

9

22102165

CDKN2B

CDKN2A

1.448

C

T

0.488

0.061

0.006

3.11E-29

rs2634071

4

111669220

PITX2

PITX2

1.622

C

T

0.219

0.079

0.007

3.64E-29

rs11642015

16

53802494

FTO

RPGRIP1L

4.826

C

T

0.432

0.058

0.006

2.69E-25

rs10455872

6

161010118

LPA

PLG

0.146

G

A

0.074

−0.104

0.011

8.20E-23

rs3176326

6

36647289

CDKN1A

CDKN1A

10.88

G

A

0.173

−0.068

0.007

2.51E-22

rs602633

1

109821511

PSRC1

CELSR2

8.63

G

T

0.207

−0.054

0.007

5.19E-16

rs1739833

1

16331108

C1orf64

ZBTB17

4.205

C

T

0.331

−0.048

0.006

7.89E-15

rs17617337

10

121426884

BAG3

BAG3

0.079

C

T

0.218

−0.050

0.007

8.88E-14

rs600038

9

136151806

ABO

SURF1

7.596

C

T

0.215

−0.049

0.007

9.44E-14

rs34163229

10

75406912

SYNPO2L

SEC24C

24

G

T

0.133

−0.056

0.008

7.40E-13

rs113437066

17

65836220

BPTF

BPTF

2.588

ATTT

A

0.197

0.061

0.010

1.81E-10

rs11746435

5

137006762

KLHL3

HNRNPA0

7.216

T

A

0.229

0.042

0.007

2.04E-10

rs2832275

21

30602994

BACH1

LTN1

1.08

T

A

0.139

−0.047

0.008

2.90E-10

rs7795282

7

74122857

GTF2I

GTF2IRD1

0.262

G

A

0.221

−0.042

0.007

7.69E-10

rs12933292

16

69566309

NFAT5

NFAT5

0.403

G

C

0.425

0.034

0.006

8.96E-10

rs216199

17

2200871

SMG6

SMG6

3.442

C

T

0.388

−0.037

0.006

1.11E-09

rs2013002

12

112200150

ALDH2

ATXN2

4.336

C

T

0.415

0.033

0.006

5.68E-09

rs17163345

1

222806218

MIA3

MIA3

7.541

G

A

0.270

−0.034

0.006

2.15E-08

rs3764351

17

37824339

PNMT

MED1

5.182

G

A

0.340

−0.033

0.006

2.27E-08

rs9349379

6

12903957

PHACTR1

PHACTR1

5.478

G

A

0.401

−0.031

0.006

2.58E-08

rs4327120

18

36532976

N/A

N/A

1.032

C

T

0.128

0.050

0.009

3.09E-08