Fig. 4: Cryo-EM structures of the Omicron BA.4/5 spike in complex with elite nAbs.

a The structures of the BA.4/5 S trimer in complex with TH003, TH027, TH236, TH272, TH132, and TH281 are displayed in cartoon representation. TH003, TH027, TH236, TH272, TH132, and TH281 are colored pink, purple blue, purple, green, yellow, and orange, respectively, and the S trimer is colored gray. Side view (top), top view (bottom). b The epitopes of antibodies are displayed in surface representation. The colors are the same as in a, and the hACE2 interface is circled in red.