Fig. 4: Independent validation of the MLMRPscore in external multicenter and cross-platform cohorts.

A summary of the samples used to validate the performance of MLMRPscore and the confusion matrix in the You cohort (A), TCGA-GTEx cohort (D), Li cohort-1 (G), and Li cohort-2 (J). Heatmap of the expression pattern of six lncRNA biomarkers with the corresponding risk probability, predicted label, and true label in the You cohort (B), TCGA-GTEx cohort (E), Li cohort-1 (H), and Li cohort-2 (K). Receiver operating characteristic (ROC) curve for the diagnostic performance of the MLMRPscore in the You cohort (C), TCGA-GTEx cohort (F), Li cohort-1 (I), and Li cohort-2 (L). In C, F, I, L, data are presented as AUC ± 95% CI. ESCC esophageal squamous cell carcinoma, ANT adjacent normal tissues, AUC area under the curve, CI confidence interval, HD healthy donors.