Fig. 3: COVID-19 vaccine induces strong antibody responses that are not enhanced following breakthrough infection.
From: Immunological imprinting of humoral immunity to SARS-CoV-2 in children
A Antibody levels specific for spike from Wuhan-Hu-1, and Omicron BA.1, BA.2, BA.4, and BA.5 were determined in children following vaccination (pink, n = 15) or BA.1/2 Omicron breakthrough infection (black, n = 6). Data were presented as arbitrary units (AU)/ml. B Neutralisation of pseudovirus-bearing ancestral B.1 or Omicron variant spike protein in children following vaccination (pink, n = 15) or BA.1/2 Omicron breakthrough infection (black, n = 6). Dashed lines indicate the limit of detection, bars indicate the geometric mean. Data were presented as NT50, the titre at which infectivity had been reduced by 50% relative to controls. Source data are provided as a Source Data file.
