Fig. 7: Loss of UHRF1 impairs tumor growth in a xenograft model of human KRAS mutant lung adenocarcinoma. | Nature Communications

Fig. 7: Loss of UHRF1 impairs tumor growth in a xenograft model of human KRAS mutant lung adenocarcinoma.

From: UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma

Fig. 7

a Flow cytometry analysis of the in vivo competitive-growth assay in A549 xenografts. Top - day 1 cell populations, bottom – example of endpoint (day 30) tumor cell populations. b Fold change in GFP/mCherry ratio between A549 tumor cell populations at endpoint and day 1 (D1) cell populations; n = 8 individual tumors assessed for control (ctrl+ctrl) and sgUHRF1-2 (ctrl+UHRF1#2) arms, n = 9 individual tumors assessed for sgUHRF1-1 (ctrl+UHRF1 #1). Lines represent means; *p = 0.0234, ***p = 6.31e-10 by anova followed by Dunnett’s test between the indicated UHRF1 sgRNA and the control sgRNA. Source data are provided as a Source data file.

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