Fig. 6: Classification of cancer samples against a healthy cohort based on the selected protein panel.
From: Next generation pan-cancer blood proteome profiling using proximity extension assay
Model results showing the cancer probability for cancer and healthy individuals from the test set (top) and the ROC curve with AUC score (bottom) for a CLL, b colorectal cancer, c ovarian cancer, d lung cancer. e Protein levels of four different proteins for cancer samples stratified into early (stage 1–2) or advanced (stage 3–4) stages as well as the healthy cohort. Boxplots summarize the median value, upper and lower hinges corresponding to the first and third quartiles, and whiskers indicating the minimum and maximum values within 1.5 times the IQR. Individual data points are presented for each cancer group, with n = 327, n = 114, n = 289, and n = 200, for ABHD14B, CD22, LGALS4, and PAEP, respectively. P-values are calculated using a two-sided t-test to compare the group means. Model results showing the cancer probability for cancer samples stratified by stage (early or advanced) and healthy individuals (top) and the ROC curve with AUC score (bottom) for f colorectal cancer and g lung cancer. The p-values are calculated using unpaired DeLong’s test. Source data are provided as a Source data file. CLL chronic lymphocytic leukemia.
